Targeted dephosphorylation of hyperphosphorylated TAU in Alzheimer’s disease
Targeted dephosphorylation of hyperphosphorylated TAU in Alzheimer’s disease
About the Project Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder. Despite several decades of preclinical and clinical research, few effective therapeutic approaches exist against AD. Thus, there … Read More Read More
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Phospho-regulation of kinetochore function during mitosis
Phospho-regulation of kinetochore function during mitosis
About the Project Accurate partition of the duplicated genome during cell division is crucial for cellular viability and organismal development. Chromosome mis-segregation is a major source of aneuploidy, and it … Read More Read More
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Unravelling the molecular mechanisms of amyotrophic lateral sclerosis / motor neuron disease
Unravelling the molecular mechanisms of amyotrophic lateral sclerosis / motor neuron disease
About the Project Amyotrophic lateral sclerosis (ALS)—the commonest type of motor neuron disease (MND)—is a rapidly progressive paralysing illness of mid-adulthood. It has a lifetime risk of ~1 in 400, … Read More Read More
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Mechanisms of Protein Phosphatase 1 regulation during oocyte meiosis
Mechanisms of Protein Phosphatase 1 regulation during oocyte meiosis
About the Project Meiosis research is of paramount importance for several aspects of human life including fertility, genetic diseases, and crop improvement. Insights into the intricate mechanisms governing the different … Read More Read More
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Development and application of new tools to study plant parasite effectors during host interactions
Development and application of new tools to study plant parasite effectors during host interactions
About the Project Plant parasites form close associations with their host plants and deliver suites of effector molecules, including proteins, inside their host essential for infection or infestation. Effector repertoires … Read More Read More
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How membrane proteins are regulated - revealing the dynamic S-acyl proteome in plants
How membrane proteins are regulated - revealing the dynamic S-acyl proteome in plants
About the Project S-acylation involves addition of fatty acids to sulfhydryl groups of cysteine residues within proteins, typically altering protein function by changing behaviour within cellular membranes. S-acylation is highly … Read More Read More
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Intraspecies Interactions In the Gram-positive bacterium Bacillus subtilis
Intraspecies Interactions In the Gram-positive bacterium Bacillus subtilis
About the Project The need to distinguish self from non-self is a requirement spanning the kingdoms from bacteria to plants and humans. Many microbes are highly clonal and frequently restrict … Read More Read More
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Understanding the beginning of life: the biological role of UBE2Q1 and non-canonical ubiquitination in mouse embryonic cells
Understanding the beginning of life: the biological role of UBE2Q1 and non-canonical ubiquitination in mouse embryonic cells
About the Project Ubiquitination is a fundamental post-translational modification (PTM), which profoundly impacts diverse cellular functions, including protein degradation, localization, quality control, DNA repair, cell signalling, and immune response. Ubiquitin … Read More Read More
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Characterisation of the impact of NICD S2513 mutation on human segmentation using iPS derived somitoids
Characterisation of the impact of NICD S2513 mutation on human segmentation using iPS derived somitoids
About the Project During early development cells differentiate into the different cell types required to form the tissues that make up the embryo. Research into human embryological development is challenging … Read More Read More
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Exploring Non-Canonical Ubiquitination and Its Biological Roles
Exploring Non-Canonical Ubiquitination and Its Biological Roles
About the Project Ubiquitination is a fundamental post-translational modification (PTM) crucial for a wide range of cellular processes, including protein degradation, localization, quality control, DNA repair, cell signaling, and immune … Read More Read More
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