Development of novel approaches to study changes in chromatin structure and investigation of the role of rDNA chromatin in malignant transformation
Development of novel approaches to study changes in chromatin structure and investigation of the role of rDNA chromatin in malignant transformation
We have developed a novel in-situ approach to characterising changes in transcription factor binding and/or histone modification which localised at the “open” chromatin. This approach allows us to sequentially visualise … Read More Read More
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The role of the histone lysine demethylase KDM4A in post-stress recovery and its utility as a target in breast and prostate cancer
The role of the histone lysine demethylase KDM4A in post-stress recovery and its utility as a target in breast and prostate cancer
This project aims to identify specific targets of histone demethylase which are involved in the post-stress survival of breast and prostate cancer cells and determine the potential of this enzyme … Read More Read More
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A study of the transcriptomic responses elicited by Salmonella to humectants used in food production - do bacteria have a memory?
A study of the transcriptomic responses elicited by Salmonella to humectants used in food production - do bacteria have a memory?
Humectants are used by the food industry for numerous reasons, such as the use of salt as flavour enhancing ingredient. They are most commonly used to reduce the moisture content … Read More Read More
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Phenotypic & molecular characterization of antimicrobial resistance (AMR) markers; dissemination mechanisms of AMR in bacteria of food-animal origin; whole genome & plasmid sequencing; bioinformatics
Phenotypic & molecular characterization of antimicrobial resistance (AMR) markers; dissemination mechanisms of AMR in bacteria of food-animal origin; whole genome & plasmid sequencing; bioinformatics
Escherichia coli is a genus of bacteria, encountered as an inhabitant of the human and animal gastrointestinal tract. Surveillance is reporting an increase in resistance to all major classes of … Read More Read More
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A study of the emergence of Clostridium difficile from across the farm-to-fork continuum
A study of the emergence of Clostridium difficile from across the farm-to-fork continuum
Recent research suggests that Clostridium difficile is an emerging foodborne pathogen of public health concern and commercial significance for the Irish agri-food sector. This project will initially undertake a systematic … Read More Read More
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Vibrio species in Irish waters
Vibrio species in Irish waters
Agri-food is the largest indigenous industry on the island of Ireland. With its long coastline of 3,171 km, the island has access to a vast marine environment supporting a vibrant … Read More Read More
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Making the most of product code pattern recognition for food fraud prevention
Making the most of product code pattern recognition for food fraud prevention
Food fraud criminals are creative. As traditional fraud fails to pay off, fraudsters learn to change their tactics. The good news is that with advances in machine learning, systems can … Read More Read More
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Investigate the nutritional potential, for ruminants, of different by-products as an alternative feed supplement for incorporation into animal feed
Investigate the nutritional potential, for ruminants, of different by-products as an alternative feed supplement for incorporation into animal feed
Nowadays, the farm livestock productions systems face multiple challenges as the consumer desires high quality animal products which are produced with less environmental impact and at the same time without … Read More Read More
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A Novel Data Integration Framework for Modeling the Adverse Outcome Pathway
A Novel Data Integration Framework for Modeling the Adverse Outcome Pathway
Endocrine disrupting chemicals (EDCs) affect a variety of hormone-regulated physiological pathways in humans and wildlife. Health effects due to EDCs include reproductive dysfunction, premature puberty, neurological disorders, impaired immune function, … Read More Read More
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Genome-wide analysis of genetic alterations in prostate cells in response to soy chemicals
Genome-wide analysis of genetic alterations in prostate cells in response to soy chemicals
Soybeans contain isoflavones which are a primary source of phytoestrogens in the human diet [1]. Based on epidemiological data from Japan, consumption of soy has been proposed to reduce the … Read More Read More
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