Self-regulating, self-cleaning biomaterials
Self-regulating, self-cleaning biomaterials
A major problem associated with medical devices is infection. With infection rates of approaching 100% in some devices, ways to prevent formation of bacterial biofilm on medical device surfaces are … Read More Read More
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Microwave-induced in situ amorphization as a strategy for modulating drug release from silicone elastomer devices for controlled release drug delivery
Microwave-induced in situ amorphization as a strategy for modulating drug release from silicone elastomer devices for controlled release drug delivery
This is an exemplar PhD project co-supervised by Dr. Min Zhao and Prof. Karl Malcolm. No funding has yet been secured for the project. We particularly welcome applications from students … Read More Read More
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The effects of gut microbiome metabolites in modulating enteroendocrine cell function and gut hormone secretion
The effects of gut microbiome metabolites in modulating enteroendocrine cell function and gut hormone secretion
Enteroendocrine cells are the most abundant endocrine cell-type in the human body. These are specialised gastrointestinal cells secreting hormones into either the circulation (for systemic actions), the extracellular space (for … Read More Read More
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Modulating the A20-DREAM axis in inflammation by drug repurposing
Modulating the A20-DREAM axis in inflammation by drug repurposing
Resolution of inflammation depends on regulated feedback through A20 (TNFAIP3) but in chronic inflammatory conditions such as cystic fibrosis (CF) and asthma A20 is significantly reduced. Clinically, A20 deficiency in … Read More Read More
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Modulating endothelial cell crosstalk within tissues to delay and/or reverse ageing
Modulating endothelial cell crosstalk within tissues to delay and/or reverse ageing
Blood vessels, running across all tissues, provide a unique biological hub that integrates ageing signals at the molecular, cellular, and organ levels. This project proposes targeting the endothelium as a … Read More Read More
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