Antibiotic Resistance and Biofilm Formation in Clinical Isolates of Enterococcus faecium – a WHO High Priority Pathogen
Antibiotic Resistance and Biofilm Formation in Clinical Isolates of Enterococcus faecium – a WHO High Priority Pathogen
E. faecium is an important human pathogen which exhibits resistance to a range of antibiotics, and is implicated in a wide variety of device associated infections. Due to its clinical … Read More Read More
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Investigating the clinical and molecular significance of the microbiome in breast cancer
Investigating the clinical and molecular significance of the microbiome in breast cancer
Breast Cancer (BC) is the most common cancer in the UK, accounting for 15% of new cancer cases. There is a significant unmet clinical need to understand why some cancers … Read More Read More
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Development of in silico framework to support pre-clinical model selection
Development of in silico framework to support pre-clinical model selection
Pre-clinical models, including cell lines, are essential to modelling diseases and treatment response in the laboratory setting. In vitro or vivo model choice can be based on personal preference or … Read More Read More
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Investigating the effects of PCSK9 on inflammation in clinically relevant human models of ARDS
Investigating the effects of PCSK9 on inflammation in clinically relevant human models of ARDS
This project will investigate the effects of a PCSK9 inhibitors, drugs developed for cholesterol reduction, on inflammatory mediator expression in cell types implicated in the development of Acute Respiratory Distress … Read More Read More
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Remote assessment for clinical trials and healthcare: Exploring the usefulness of remote spirometry
Remote assessment for clinical trials and healthcare: Exploring the usefulness of remote spirometry
The COVID-19 pandemic and pressure on healthcare systems has increased use of remote spirometry for monitoring of respiratory patients. These portable spirometers have been advocated by healthcare providers and positively … Read More Read More
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Exploration of therapeutic potential of MSC mitochondria transplantation in the pre-clinical models of Acute Respiratory Distress Syndrome
Exploration of therapeutic potential of MSC mitochondria transplantation in the pre-clinical models of Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome (ARDS) is a major cause of mortality in the critically ill patients with no effective pharmacological treatment. We previously reported that mitochondrial dysfunction and associated oxidative … Read More Read More
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