Development of PROTAC-based technology to inhibit inflammation
Development of PROTAC-based technology to inhibit inflammation
About the Project Inflammation is a central driver of numerous major diseases including cardiovascular indications, with the inflammasome and neutrophil extracellular traps (NETs) playing key roles in inflammatory processes.1 This … Read More Read More
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RNA therapy development for inherited eye diseases
RNA therapy development for inherited eye diseases
About the Project Applications are welcomed for self-funded students to pursue a PhD in RNA therapeutics. The PhD project will use short activating RNAs to specifically increase target gene expression … Read More Read More
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Sperm derived factors involved in egg activation.
Sperm derived factors involved in egg activation.
About the Project At the fertilization in mammals the sperm initiates a series of Ca2+ oscillations by introducing PLCzeta into the egg. These Ca2+ oscillations activate embryo development. There is … Read More Read More
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High-performance ultrafast fibre lasers for biomedical applications
High-performance ultrafast fibre lasers for biomedical applications
About the Project Supervisory Team : Dr Lin Xu, Prof David Richardson Ultrafast lasers providing femtosecond pulses are enabling a rapidly increasing range of applications in science and industry, including … Read More Read More
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Fibre laser based mid infrared sources and their applications
Fibre laser based mid infrared sources and their applications
About the Project Supervisory Team : Dr Lin Xu, Prof David Richardson Project Description The mid-infrared (mid-IR) spectral region of 2-20 µm contains strong characteristic vibrational transitions of many important … Read More Read More
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Determining molecular mechanisms of action of anti-obesity medications in neural stem cells and neurons
Determining molecular mechanisms of action of anti-obesity medications in neural stem cells and neurons
About the Project medications in neural stem cells and neurons Project Description (Max 700 words) Project Overview Due to the increasing prevalence of obesity, Anti-Obesity Medications (AOMs) are among the … Read More Read More
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Synthetic mRNA for re-programming and gene editing of human dental pulp stem cells
Synthetic mRNA for re-programming and gene editing of human dental pulp stem cells
About the Project 'TO APPLY, PLEASE CLICK INSTITUTION WEBSITE' Project start date: October 1st 2025 Research Project Description: Synthetic mRNA offers a powerful and flexible reprogramming platform that can alter … Read More Read More
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Targeted dephosphorylation of hyperphosphorylated TAU in Alzheimer’s disease
Targeted dephosphorylation of hyperphosphorylated TAU in Alzheimer’s disease
About the Project Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder. Despite several decades of preclinical and clinical research, few effective therapeutic approaches exist against AD. Thus, there … Read More Read More
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Phospho-regulation of kinetochore function during mitosis
Phospho-regulation of kinetochore function during mitosis
About the Project Accurate partition of the duplicated genome during cell division is crucial for cellular viability and organismal development. Chromosome mis-segregation is a major source of aneuploidy, and it … Read More Read More
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Unravelling the molecular mechanisms of amyotrophic lateral sclerosis / motor neuron disease
Unravelling the molecular mechanisms of amyotrophic lateral sclerosis / motor neuron disease
About the Project Amyotrophic lateral sclerosis (ALS)—the commonest type of motor neuron disease (MND)—is a rapidly progressive paralysing illness of mid-adulthood. It has a lifetime risk of ~1 in 400, … Read More Read More
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